We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1.
- Authors
Wan, Michael; Ullrich, Nicole; Manley, Peter; Kieran, Mark; Goumnerova, Liliana; Heidary, Gena
- Abstract
Sporadic optic pathway gliomas (OPGs) have been reported to cause more vision loss than OPGs associated with neurofibromatosis type-1, but long-term visual outcome data are limited. The purpose of this study was to report the visual outcomes of a cohort of pediatric patients with sporadic OPGs. This was a retrospective, cohort study at a tertiary care pediatric hospital and cancer institute. The study included all patients with sporadic OPGs evaluated from 1990 to 2014. The primary outcome was visual acuity at final follow-up. Secondary outcomes were risk factors for a poor visual outcome and the rate of progression. There were 59 pediatric patients included in the study. Median age at presentation was 2.5 years old and median follow-up was 5.2 years. In the worse eye at final follow-up, 16 patients (27 %) were 20/30 or better, 9 patients (15 %) were between 20/40 and 20/80, and 34 patients (58 %) were 20/100 or worse. In the better eye at final follow-up, 33 patients (56 %) were 20/30 or better, 11 patients (19 %) were between 20/40 and 20/80, and 15 patients (25 %) were 20/100 or worse. Risk factors for a poor visual outcome included younger age at presentation, optic nerve pallor, and tumor extent. Of the 54 patients (92 %) who received treatment, 40 (74 %) experienced disease progression during or after treatment. A majority of pediatric patients with sporadic OPGs had significant long-term visual impairment. In spite of treatment, tumor progression is common. Serial ophthalmic examinations with quantitative vision measurements are essential in the management of sporadic OPGs.
- Subjects
GLIOMAS; OPTIC nerve tumors; NEUROFIBROMATOSIS 1; JUVENILE diseases; TERTIARY care; RETROSPECTIVE studies; DIAGNOSIS
- Publication
Journal of Neuro-Oncology, 2016, Vol 129, Issue 1, p173
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-016-2163-4