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- Title
Stereoselective conjugate addition of ketones to alkylidene malonates using thiourea‐sulfonamide organocatalyst.
- Authors
Kawada, Masahiro; Nakashima, Kosuke; Hirashima, Shin‐ichi; Sakagami, Toru; Koseki, Yuji; Miura, Tsuyoshi
- Abstract
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea‐sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.
- Subjects
STEREOSELECTIVE reactions; KETONES; ALKYLIDENES; MALONATES; SULFONAMIDES
- Publication
Chirality, 2018, Vol 30, Issue 11, p1215
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.23015