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- Title
Effect of melatonin on cholestatic oxidative stress under constant light exposure.
- Authors
Adolfo Cruz; Francisco J. Padillo; Jose Granados; Isaac Túnez; M. Carmen Muñoz; Javier Briceño; Carlos Pera-Madrazo; Pedro Montilla
- Abstract
This study was designed to evaluate the effect of melatonin on cholestatic oxidative stress under constant light exposure. Cholestasis was induced by double ligature and section of the extra-hepatic bile duct. Melatonin was injected i.p.(1000 μg kg-1 day-1). Malondialdehyde, reduced glutathione, catalase, superoxide dismutase, glutathione reductase, peroxidase and transferase were determined in liver. After bile-duct obstruction and under constant light exposure, an increase in malondialdehyde (p < 0.05) and a slight decrease in reduced glutathione were seen. Enzyme activity, with the exception of glutathione reductase, had significantly diminished. After melatonin administration, malondialdehyde fell (p < 0.001), whereas there was an increase in reduced glutathione (p < 0.0001) compared with untreated controls. Constant light exposure was associated with an increase in hepatic oxidative stress. Treatment with melatonin decreased lipid peroxide synthesis, and permitted a recovery of both reduced glutathione and scavenger enzyme activity. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
MELATONIN; CHOLESTASIS; BILE ducts; ENZYMES
- Publication
Cell Biochemistry & Function, 2003, Vol 21, Issue 4, p377
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.1046