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- Title
Sesamol attenuates bleomycin‐induced pulmonary toxicity and fibrosis in experimental animals.
- Authors
Kaushik, Swati; Bhargava, Poorva; Sharma, Jatin; Arava, Sudheer; Nag, Tapas C.; Arya, Dharamvir S.; Bhatia, Jagriti
- Abstract
Sesamol, a lignan obtained from roasted seeds of Sesamum indicum, has high antioxidant and anti‐inflammatory activity. In this study, we have investigated the effect of sesamol on Bleomycin (BLM) induced pulmonary toxicity as well as fibrosis in Wistar rats. Lung toxicity was induced by administration of BLM, 0.015 U/g ip, twice weekly for 28 days whereas lung fibrosis was induced by BLM, 0.015 U/g ip, every 5th day for 49 days. Sesamol administration was started 7 days before first dose of BLM in both the models. It was observed that sesamol 50 mg/kg most effectively attenuated pulmonary toxicity by reducing oxidative stress, inflammation and apoptosis. This dose was further evaluated for its anti‐fibrotic effect. It was observed that there was a significant reduction in fibrosis. Lung collagen content was markedly reduced. Furthermore, expression of pro‐fibrotic proteins, TGF‐β/SMAD and α‐SMA, was reduced and that of anti‐fibrotic protein, AMPK, was markedly increased. Even though the combination of sesamol with pirfenidone exhibited no additional protection than either drug alone, it is evident from our study that our test drug, sesamol is comparable in efficacy to pirfenidone. Thus, sesamol has promising therapeutic potential in treatment of pulmonary toxicity and fibrosis.
- Subjects
PULMONARY fibrosis; LABORATORY animals; SESAME; AMP-activated protein kinases; ANTI-inflammatory agents
- Publication
Journal of Biochemical & Molecular Toxicology, 2023, Vol 37, Issue 11, p1
- ISSN
1095-6670
- Publication type
Article
- DOI
10.1002/jbt.23472