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- Title
Effect of early administration of tolvaptan on pleural effusion post-hepatectomy.
- Authors
Iida, Hiroya; Maehira, Hiromitsu; Mori, Haruki; Nitta, Nobuhito; Maekawa, Takeru; Takebayashi, Katsushi; Kaida, Sachiko; Miyake, Toru; Tani, Masaji
- Abstract
Purpose: This study evaluated the efficacy of tolvaptan administration at the early stage after hepatectomy to control pleural effusion and improve the postoperative course. Methods: Patients were administered tolvaptan (7.5 mg) and spironolactone (25 mg) from postoperative day 1 to postoperative day 5 (tolvaptan group, n = 68) for 13 months. Early administration of tolvaptan was not provided in the control group (n = 68); however, diuretics were appropriately administered according to the patient's condition. The amount of pleural effusion on computed tomography on postoperative day 5 was compared between the two groups. Results: The amount of pleural effusion and increase in body weight on postoperative day 5 showed significant differences in both groups (p < 0.001 and p = 0.019, respectively). However, the rate of pleural aspiration and the duration of postoperative hospitalization were comparable between the groups. The amount of intraoperative blood loss and lack of early administration of tolvaptan were identified as independent risk factors contributing to pleural effusion on multivariate analysis. Conclusion: Early administration of tolvaptan to patients after hepatectomy was found to be capable of controlling postoperative pleural effusion and increase in body weight, but it did not reduce the rate of pleural aspiration or the hospitalization period.
- Subjects
PLEURAL effusions; SURGICAL blood loss; COMPUTED tomography; ASPIRATORS; PLEURODESIS
- Publication
Langenbeck's Archives of Surgery, 2023, Vol 408, Issue 1, p1
- ISSN
1435-2443
- Publication type
Article
- DOI
10.1007/s00423-023-03136-4