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- Title
The effects of Atm haploinsufficiency on mutation rate in the mouse germ line and somatic tissue.
- Authors
Akshay K. Ahuja; Ruth C. Barber; Robert J. Hardwick; Michael M. Weil; Paula C. Genik; David J. Brenner; Yuri E. Dubrova
- Abstract
Using single-molecule polymerase chain reaction, the frequency of spontaneous and radiation-induced mutation at an expanded simple tandem repeat (ESTR) locus was studied in DNA samples extracted from sperm and bone marrow of Atm knockout (Atm+/−) heterozygous male mice. The frequency of spontaneous mutation in sperm and bone marrow in Atm+/− males did not significantly differ from that in wild-type BALB/c mice. Acute exposure to 1 Gy of γ-rays did not affect ESTR mutation frequency in bone marrow and resulted in similar increases in sperm samples taken from Atm+/− and BALB/c males. Taken together, these results suggest that the Atm haploinsufficiency analysed in our study does not affect spontaneous and radiation-induced ESTR mutation frequency in mice.
- Subjects
RODENTS; BIRCH mice; BRUSH mouse; DANCING mice
- Publication
Mutagenesis, 2008, Vol 23, Issue 5, p367
- ISSN
0267-8357
- Publication type
Article
- DOI
10.1093/mutage/gen028