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- Title
Cytogenetic Evidence of Gene Amplification in Urothelial Cancer - A Possible Mechanism of Tumor Invasiveness.
- Authors
Milašin, Jelena; Mićić, Sava
- Abstract
A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder and ureter. None of the 75 low-grade low-stage tumors contained this karyotypic anomaly. It is obvious that double minutes are not a rare and sporadic phenomenon in this type of tumors; additionally there is strong evidence that they are involved in tumor progression, i.e. they are associated with tumor aggressiveness and unfavorable prognosis. Copyright © 1992 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1992, Vol 48, Issue 3, p258
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282346