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- Title
Characteristics of Neoplastic Progression and Tumor Behavior in Skin Carcinogenesis by Different Methods.
- Authors
Stenbäck, Frej
- Abstract
Characteristics of chemically induced skin tumor formation by different methods were studied in 600 Swiss mice. A large dose of 9, 10-dimethylbenz(a) anthracene (DMBA) alone or followed by 12-0-tetra-decanoyl-phorbol-13-acetate(TPA) and a small dose of DMBA followed by TPA or DMBA repeatedly induced papillomas in 80-90% of the animals. Of these 44-65% regressed and 11-16% became malignant. Keratoacanthomas, observed mainly in repeated DMBA treated animals, were seen to arise de novo in 1-12% of the animals, or from papillomas, 3-12%, they became malignant in 4-9% of the animals. Squamous cell carcinomas were formed de novo in 1-8% of the animals or from papillomas or keratoacanthomas in 10-14% of the animals. Duration of experiment and degree of malignancy related to size of tumor and level of invasion. It is concluded that tumor formation is a stepwise process, with the different types of treatment affecting different aspects of tumor formation to a varying degree. Copyright © 1980 S. Karger AG, Basel
- Publication
Oncology, 1980, Vol 37, Issue 3, p163
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225427