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- Title
Placental Volume at 11-13 Weeks' Gestation in the Prediction of Birth Weight Percentile.
- Authors
Plasencia, Walter; Akolekar, Ranjit; Dagklis, Themistoklis; Veduta, Alina; Nicolaides, Kypros H.
- Abstract
Objective: To determine the value of placental volume measured by 3D ultrasound at 11-13 weeks' gestation in combination with maternal characteristics and serum pregnancy-associated plasma protein-A (PAPP-A) in the prediction of small and large for gestational age (SGA and LGA) neonates. Methods: Maternal serum PAPP-A and placental volume were measured at 11-13 weeks in 3,104 singleton pregnancies. Regression analysis was used to examine the contribution of maternal characteristics, placental volume and PAPP-A in the prediction of SGA and LGA neonates. Results: There was a significant association between placental volume and PAPP-A (r = 0.268, p < 0.0001). Median placental volume and PAPP-A, expressed as multiples of the median (MoM) in appropriate for gestational age (AGA) neonates, were reduced in the SGA group (placental volume 0.88 MoM, vs. 1.00 MoM in AGA, p < 0.0001; PAPP-A 0.92 MoM vs. 1.00 MoM in AGA, p = 0.019) and increased in the LGA group (placental volume 1.09 MoM vs. 1.00 MoM in AGA, p < 0.0001; PAPP-A 1.15 MoM vs. 1.00 MoM in AGA, p = 0.015). Maternal characteristics with either placental volume or PAPP-A detected about 30% of the SGA or LGA neonates, at a false positive rate of 10%. Conclusion: Measurement of placental volume and serum PAPP-A can improve the prediction of SGA or LGA neonates provided by maternal characteristics alone. Copyright © 2011 S. Karger AG, Basel
- Subjects
PLACENTA; FIRST trimester of pregnancy; BIRTH weight; REGRESSION analysis; GESTATIONAL age; MEDICAL imaging systems; THREE-dimensional imaging; PREDICTION models; MEDICAL screening
- Publication
Fetal Diagnosis & Therapy, 2011, Vol 30, Issue 1, p23
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000324318