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- Title
Motors and switches: AAA+ machines within the replisome.
- Authors
Davey, Megan J.; Jeruzalmi, David; Kuriyan, John; O'Donnell, Mike
- Abstract
Clamp loaders are required to load the ring-shaped clamps that tether replicative DNA polymerases onto DNA. Recently solved crystal structures, along with a series of biochemical studies, have provided a detailed understanding of the clamp loading reaction. In particular, studies of the Escherichia coli clamp loader — an AAA+ machine — have provided insights into the architecture of clamp loaders from eukaryotes, bacteriophage T4 and archaea. Other AAA+ proteins are also involved in the initiation of DNA replication, and studies of the E. coli clamp loader indicate mechanisms by which these proteins might function.
- Subjects
DNA replication; MICROBIOLOGY; PROTEINS
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 11, p826
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm949