We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Infectious disease: Hushing mTOR boosts immunity to pathogens.
- Authors
Bordon, Yvonne
- Abstract
The article presents a study which investigates how the immune system can distinguish pathogenic and non-pathogenic strains of the same infection. It involves a comparison of post-translational modifications of proteins from macrophages with the pathogenic Legionella pneumophila or with a non-pathogenic mutant of the bacterium. Results suggests that phosphoinositide 3-kinase (PI3K), AKT, and mTOR were ubiquitylated in macrophages with L. pneumophila while phosphorylated in the mutant strain.
- Subjects
IMMUNE response; MACROPHAGES; PATHOGENIC bacteria; HOST-parasite relationships; LEGIONELLA pneumophila; PHOSPHOINOSITIDES; PROTEIN kinase B; MTOR protein
- Publication
Nature Reviews Immunology, 2013, Vol 13, Issue 12, p847
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3562