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- Title
A New Class of Tyrosinase Inhibitors for Skin Luminosity.
- Authors
Hettwer, S.; Gyenge, E. Besic; Schoeffel, L.; Suter, B.; Obermayer, B.
- Abstract
Although some skin-lightening cosmetic raw materials already exist, their effectiveness particularly on human tyrosinase has not been directly measured in every case or has not shown convincing performance in-vitro. Some active ingredients are even irritating to the skin and are restricted accordingly by some cosmetics legislations. The search for new, skin-friendlier skin-lightening raw materials has led to the development of promising candidates in recent years. Here we present a barley germ extract containing a new class of active ingredients - hordatines - with superior tyrosinase inhibition properties. The great potential of these molecules was revealed with the help of artificial intelligence by molecular docking to the tyrosinase structure.
- Subjects
SKIN color lighteners; COSMETICS; PHENOL oxidase; RAW materials; ARTIFICIAL intelligence
- Publication
SOFW Journal (English version), 2024, Vol 150, Issue 4, p24
- ISSN
2750-2937
- Publication type
Article