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- Title
To evaluate clinical utility of MUM-1 IHC to detect chronic endometritis due to genital tuberculosis.
- Authors
Punjabi, Ashita; Mondal, Rana; Mishra, Jharna; Agrawal, Pallavi; Chittawar, Priya Bhave
- Abstract
Introduction: Due to its paucibacillary nature, diagnostic tests to detect genital tuberculosis (GTB) suffer from low detection rate. Endometrium is involved in about 50% cases of GTB. Multiple myeloma 1 transcription factor immunohistochemistry (MUM-1 IHC), a marker of plasma cells, has been shown as a sensitive marker for detecting chronic endometritis. Aim: The aim of this study is to evaluate the clinical utility of MUM-1 IHC to detect endometrial involvement and chronic endometritis in GTB. Materials and Methods: This was a retrospective study conducted in a reproductive medicine unit. Three hundred ninetyone infertile patients who underwent hysterolaparoscopy and in whom MUM-1 IHC was done in the period from May 2019 to December 2020 were included in the study. Diagnosis of GTB was made on laparoscopic findings of tubercles, caseation, dense pelvic adhesions, encysted fluid, tubo-ovarian mass, and cornual blockage in accordance with index tuberculosis (TB) guidelines for extrapulmonary TB in India. Results: Sixty cases of GTB were diagnosed based on laparoscopic findings. Out of 60 patients, MUM-1 IHC was positive in 28 cases and negative in 32 cases. GeneXpert was negative in all 60 cases of laparoscopydiagnosed GTB. Histopathology was positive in nine cases of GTB. Sensitivity and specificity of the test are 46.66 and 85.80%, respectively. Conclusion: MUM-1 IHC can be proven as a useful marker to rule out endometrial involvement in GTB owing to its high specificity and can be recommended in conditions in which histopathology and GeneXpert are negative; however, prospective studies are needed to confirm the findings of the present study.
- Subjects
DISEASE progression; ENDOMETRIAL diseases; IMMUNOHISTOCHEMISTRY; CHRONIC diseases; GENITAL diseases; RETROSPECTIVE studies; TUBERCULOSIS; DESCRIPTIVE statistics; MULTIPLE myeloma; SENSITIVITY &; specificity (Statistics); TRANSCRIPTION factors; DATA analysis software; LONGITUDINAL method
- Publication
Fertility Science & Research, 2023, Vol 10, Issue 2, p94
- ISSN
2394-4285
- Publication type
Article
- DOI
10.4103/fsr.fsr_35_22