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- Title
Human exposure to indoor residential cyfluthrin residues during a structured activity program.
- Authors
Williams, Ryan L; Bernard, Craig E; Krieger, Robert I
- Abstract
Estimations of absorbed daily dosage (ADD) of chemicals following contact with treated surfaces may be required for risk assessment and risk management. Measurements of ADD based upon biomonitoring are a more reliable data than estimates of ADD from environmental measurements since they require fewer default assumptions. Study participants performed a structured activity program (SAP) 24-h after an application of Tempo® 20 WP (cyfluthrin; 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxy-phenyl)-methyl ester) on a medium pile, plush nylon carpet. Measurements of total cyfluthrin residue and transferable cyfluthrin residue (cotton cloth and CDFA roller; personal sock and short dosimetry) were made at 3, 7, 12, 23, 47.5, and 407.5 h. Total cyfluthrin residue extracted from (Soxhlet extraction) carpet was 11.1è 2.7 μg/cm[SUP2]1 h prior to the SAP. Transferable cyfluthrin residue obtained through analysis of cotton cloths rolled with a weighted 30-pound cylinder was 0.11 μg/cm[SUP2]. Cyfluthrin residues from socks and shorts were 0.74è 0.23 and 0.15è 0.03 μg/cm[SUP2], respectively. Urine was collected at 12-h intervals during a 72-h period following the SAP and was analyzed for the cyfluthrin biomarker, 4-fluoro-3-phenoxybenzoic acid (FPBA). The mean cyfluthrin equivalents excreted were 8.4è 5.7 μg/person (yielding an absorbed dosage of 0.10 μg/kg; n = 7). The elimination half-life was 1675 h. All predicted ADDs based upon environmental measurements overestimated the ADDs measured by urinary excretion.
- Subjects
RISK management in business; EFFECT of chemicals on human cell culture; MEN'S health
- Publication
Journal of Exposure Analysis & Environmental Epidemiology, 2003, Vol 13, Issue 2, p112
- ISSN
1053-4245
- Publication type
Article
- DOI
10.1038/sj.jea.7500257