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- Title
Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus.
- Authors
Kubo, Shoji; Tanaka, Hiromu; Takemura, Shigekazu; Yamamoto, Satoshi; Hai, Seikan; Ichikawa, Tsuyoshi; Kodai, Shintaro; Shinkawa, Hiroji; Sakaguchi, Hiroki; Tamori, Akihiro; Habu, Daiki; Nishiguchi, Shuhei
- Abstract
Aim: Patients with high serum hepatitis B virus (HBV) DNA concentrations are at high risk of tumor recurrence after liver resection for HBV-related hepatocellular carcinoma (HCC). Methods: Among 24 patients with high serum HBV DNA concentrations who underwent liver resection for HBV-related HCC, postoperative lamivudine therapy was chosen by 14 (lamivudine group). The other 10 patients were controls. Results: Clinicopathologic findings did not differ between the groups. Tumor-free survival rate after surgery was significantly higher in the lamivudine than the control group ( P = 0.0086). By univariate analysis, multiple tumors were also a risk factor for a short tumor-free survival. By multivariate analysis, lack of lamivudine therapy and multiple tumors were independent risk factors for a short tumor-free survival. In four patients YMDD mutant viruses were detected after beginning lamivudine administration; in two of them, adefovir dipivoxil was administered because of sustained serum alanine aminotransferase elevations. Conclusion: Lamivudine therapy improved tumor-free survival rate after curative resection of HBV-related HCC in patients with high serum concentrations of HBV DNA, although careful follow up proved necessary for the detection of YMDD mutant viruses.
- Subjects
HEPATITIS B virus; LIVER cancer; HEPATITIS viruses; TUMORS; ALANINE aminotransferase; SURGICAL excision
- Publication
Hepatology Research, 2007, Vol 37, Issue 2, p94
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00013.x