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- Title
Ribosome ADP‐ribosylation: A mechanism for maintaining protein homeostasis in cancers.
- Authors
Ni, Jie; Gao, Jiayin; Li, Qin
- Abstract
A recent study suggests that ribosome MARylation in cancers maintains proteostasis by reducing protein synthesis and preventing toxic protein aggregation. Mechanistically, NMNAT‐2 is a cytosolic NAD+ synthase that supports the catalytic activity of PARP‐16, which mediates ribosomal proteins MARylation. Ribosomal protein MARylation regulates polysomes assembly or function through the 3′‐untranslated region (3′‐UTR) stem‐loop secondary structures in mRNAs, resulting in reduced protein synthesis and preventing toxic protein aggregation, thus supporting the growth of cancer cells during accelerated cell growth. When PARP‐16 or NMNAT‐2 is deleted, the stem‐loop element in the 3′‐UTRs of mRNAs increases polysome loading, enhances protein synthesis, promotes toxic protein aggregation, leading to inhibited cancer cell growth. Collectively, ribosome MARylation provides us with an exciting and scientific direction for us to understand cancers.
- Subjects
ADP-ribosylation; CELL aggregation; RIBOSOMAL proteins; NAD+ synthase; RIBOSOMES; CANCER cell growth; PROTEIN synthesis; HOMEOSTASIS
- Publication
Cell Biology International, 2022, Vol 46, Issue 3, p333
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.11745