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- Title
The role of mood disorders in the longitudinal course of obsessive-compulsive disorder: Preliminary data from a 20-year prospective follow-up study.
- Authors
Bramante, S.; Borsotti, A.; Rigardetto, S.; Maina, G.
- Abstract
Introduction: Although OCD is believed to have a chronic course, little research has been conducted on this, and there are discrepant findings. Studies over the last years have found that a significant proportion of patients with OCD shows symptomatic remission over long term, however there are significant variations in sampling, clinical characteristics, follow-up, and outcome assessments. Objectives: The present prospective study aims to examine rates of OCD remission after 20 years of follow up and to explore demographic and clinical predictors of remission. Methods: The study sample consists of adult patients with a principal OCD diagnosis and Y-BOCS total score =16, who have been referred to the Department of Neuroscience, University of Turin (Italy). OCD symptoms were assessed every 5 years over the 20-year follow-up period. Course data were examined using standard survival analysis methods; Cox proportional hazards regression was used to estimate relative hazards for predictors of remission. Results: Therewere 360 participants in the study. At year 20, the 28.7 %of the total sample showedOCDremission. Predictor of remission were female gender, lower Y-BOCS mean scores at study entry, longer duration of illness and comorbidity with major depressive disorder. No specific predictors of full remission were found. Lower Y-BOCS mean scores and comorbid bipolar disorder predicted partial remission. Conclusions: This study suggests that a significant proportion of patients with OCD shows remission. Future studies are needed to clearly identify predictors of remission.
- Subjects
UNIVERSITA di Torino; OBSESSIVE-compulsive disorder; AFFECTIVE disorders; MENTAL depression; LONGITUDINAL method; DISEASE remission; BIPOLAR disorder
- Publication
European Psychiatry, 2021, Vol 64, pS135
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1192/j.eurpsy.2021.374