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- Title
COMPUTERISED CYTOMORPHOMETRY IN CERVICAL NEOPLASIA.
- Authors
Marcu, Simona; Fülöp, Emöke; Tilincă, Mariana; Cheşcă, Antonella
- Abstract
Cervical cancer is the most frequent form of cancer worldwide that develops after a long period of time from a precursor lesion, the cervical intraepithelial neoplasia, CIN. Assessment of the evolutive phase of cervical neoplasia may be performed by quantitative measuring methods, morphometric and stereological measurements, at cellular and tissular level, next to the conventional, descriptive and semiquantitative, histopathological methods. Cytomorphometric measurements represent a more objective method in appreciating the prognostic in cervical cancer, based on the aspect of tumor cells and their nuclei and nucleolus, by estimating the rate of mitoses and also the volume percentage of the structural components of the tumor and the interrelations between them. In this respect quantitative morphological studies were performed on the most representative cases of cervical neoplasic lesions, namely intraepithelial neoplasias, in situ and microinvasive carcinomas, invasive epidermoid carcinomas and adenocarcinomas. The quantitative studies by computerised cytomorphometry may demonstrate the existence of a gradual, continuous evolution, proportional to the severity of the lesion.
- Subjects
CERVICAL cancer; CANCER cells; ADENOCARCINOMA; WOMEN'S health; CANCER research
- Publication
Annals of the Romanian Society for Cell Biology, 2010, Vol 15, Issue 2, p101
- ISSN
2067-3019
- Publication type
Article