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- Title
[<sup>18</sup>F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.
- Authors
Bevan Jones, W. Richard; Cope, Thomas E.; Passamonti, Luca; Fryer, Tim D.; Hong, Young T.; Aigbirhio, Franklin; Kril, Jillian J.; Forrest, Shelley L.; Allinson, Kieren; Coles, Jonathan P.; Simon Jones, P.; Spillantini, Maria G.; Hodges, John R.; O'Brien, John T.; Rowe, James B.
- Abstract
The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F] AV-1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of neuropathology seen in her father. Given the genetic diagnosis and the non-Alzheimer's pathology, these findings suggest that [18F] AV-1451 might be a useful biomarker in primary tauopathies. Largerscale in vivo and post-mortem studies will be needed to assess the technique's specificity.
- Subjects
FRONTOTEMPORAL dementia; RADIOLIGAND assay; NEUROLOGICAL disorders; HUMAN chromosome abnormality diagnosis; GENETIC mutation
- Publication
Annals of Clinical & Translational Neurology, 2016, Vol 3, Issue 12, p940
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.366