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- Title
直接抗病毒药物对 HCV 相关肝细胞癌根治性治疗后 复发影响的 Meta 分析.
- Authors
刘宇维; 金晶兰; 任天羿; 高修竹; 李杰; 朱倩; 牛俊奇
- Abstract
Objective To investigate the effect of direct - acting antiviral (DAA) on the recurrence of hepatitis C virus (HCV) - related hepatocellular carcinoma (HCC) after curative treatment. Methods PubMed, Web of Science, Cochrane Library, CNKI, CBM, Wanfang Data, and VIP were searched for the clinical studies of DAA and the recurrence of HCV - related HCC published up to April 2020. Stata 14.0 software was used to perform the meta - analysis. The Cochran Q test was used to evaluate heterogeneity between studies; the fixed effects model was used for non - heterogeneous data, and the random effects model was used for heterogeneous data. The Egger regression method or the Begg rank correlation method was used to evaluate the presence or absence of publication bias. Results A total of 10 articles (11 studies) were included in our study, among which 8 articles (9 studies) compared the effect of DAA versus the absence of anti - HCV therapy on the recurrence of HCC after curative treatment. There were 991 patients in DAA group and 808 patients in untreated group. The results of the meta - analysis showed that DAA reduced the recurrence rate of HCC after curative treatment in patients with HCV infection (hazard ratio [HR] = 0.42, 95% confidence interval [CI] : 0.28? 0.36, P < 0.001) . Three articles compared the effect of DAA versus interferon for the treatment of hepatitis C on the recurrence of HCC after curative treatment, with 267 patients in DAA group and 212 in interferon group, and the results of the meta - analysis showed that DAA and interferon had a similar effect on the recurrence rate of HCV - related HCC (HR = 0.85, 95% CI: 0.64 -1. 15, P = 0.298). Conclusion Both interferon and DAA can significantly reduce the recurrence risk of HCV - related HCC after curative treatment, with no significant difference between them.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2020, Vol 36, Issue 12, p2714
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2020.12.015