We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes.
- Authors
Razdan, Shantanu; Patel, Vishal; Jewell, Sarah; McCarthy, Colleen; Razdan, Shantanu N; McCarthy, Colleen M
- Abstract
<bold>Purpose: </bold>Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient's perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and (3) identify predictors of HRQOL post-BPM. <bold>Methods: </bold>We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched. <bold>Results: </bold>The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post-BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post-BPM. <bold>Conclusion: </bold>There is a paucity of high-quality data on outcomes of different HRQOL domains post-BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM.
- Subjects
MASTECTOMY; BREAST cancer; CANCER prevention; QUALITY of life; BRCA proteins; GENETIC mutation; SYSTEMATIC reviews; BREAST tumor prevention; BODY image; MAMMAPLASTY; PATIENT satisfaction; SEXUAL dysfunction; RESEARCH funding; PSYCHOLOGICAL factors
- Publication
Quality of Life Research, 2016, Vol 25, Issue 6, p1409
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1007/s11136-015-1181-6