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- Title
Anticancer activity of Kalanchoe tubiflora extract against human lung cancer cells in vitro and in vivo.
- Authors
Hsieh, Yi‐Jen; Huang, Hsuan‐Shun; Leu, Yann‐Lii; Peng, Kou‐Cheng; Chang, Chih‐Jui; Chang, Meng‐Ya
- Abstract
Uncontrolled cell proliferation is a common feature of human cancer. Some of herbal extract or plant-derived medicine had been shown as an important source of effective anticancer agents. We previously reported that an n-BuOH-soluble fraction of Kalanchoe tubiflora has antiproliferative activity by inducing mitotic catastrophe. In this study, we showed that the H2O-soluble fraction of Kalanchoe tubiflora (KT-W) caused cell cycle arrest, and senescence-inducing activities in A549 cells. We used 2 dimensional PAGE to analyze the protein expression levels after KT-W treatment, and identified that the energy metabolism-related proteins and senescence-related proteins were disturbed. In vivo experiments showed that the tumor growths in A549-xenografted nude mice were effectively inhibited by KT-W. Our findings implied that KT-W is a putative antitumor agent by inducing cell cycle arrest and senescence. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1663-1673, 2016.
- Subjects
KALANCHOE; ANTINEOPLASTIC agents; LUNG cancer; EXTRACTS; ALTERNATIVE medicine; HERBAL medicine; CELL cycle
- Publication
Environmental Toxicology, 2016, Vol 31, Issue 11, p1663
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.22170