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- Title
Association between exercise training and açai on calcium homeostasis and inflammation in the heart of rats submitted to a high-fat diet.
- Authors
Neiva Lavorato, Victor; Coutinho de Miranda, Denise; Bernardes Leite, Luciano; Eustáquio Silva, Marcelo; Natali, Antônio José
- Abstract
The aim of the present study was to investigate the effects of the association of treatments with aerobic exercise training (AET) and açai supplementation on calcium homeostasis (Ca2+) and inflammatory markers of the heart of rats submitted to a high-fat diet. Fisher rats were used, divided into five experimental groups: Control (C), High-fat Diet (H); High-fat Diet + Açai (HA); Highfat Diet + AET (HT); High-fat Diet + Açai + AET (HAT). The groups fed a high-fat diet received 21.8% lard and 1% cholesterol. The groups supplemented with lyophilized açai received 1% of açai in the diet. The animals in the trained groups were submitted to a progressive treadmill running program for 8 weeks. At the end, the hearts were dissected, and the left ventricles separated for realtime PCR analysis. The HT group had higher gene expression of ryanodine receptor type 2 (RyR2) compared to group H. Regarding the sodium/calcium exchanger (NCX), group H had lower gene expression compared to the other groups. Interleukin 10 (IL-10) was high in group HT when compared to group H. The treatments changed parameters of Ca2+ homeostasis and inflammation, but the association of interventions did not provide additional effects.
- Subjects
HIGH-fat diet; EXERCISE therapy; HOMEOSTASIS; RYANODINE receptors; AEROBIC exercises; CALCIUM
- Publication
Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación, 2024, Vol 55, p302
- ISSN
1579-1726
- Publication type
Article
- DOI
10.47197/retos.v55.103103