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- Title
Effects of Polygonatum sibiricum Polysaccharide (PSP) on Inflammatory Factors in Rats Fed on High-fat Diet.
- Authors
Mingzhe SU; Mingjun LI; Lingli BAI; Chenzhong JIN; Yihong HU; Yan WANG
- Abstract
[Objectives] This study was conducted to explore the effects of Polygonatum sibiricum polysaccharide (PSP) on chronic intestinal inflammation caused by high-fat diet. [Methods] Thirty five male healthy SD rats were randomly divided into a normal control group (NC, normal diet, n = 10) and a high-fat diet group (HF, high-fat diet, n =25). After 8 weeks, an obesity model was established. The HF group was randomly divided into an HF group and a PSP treatment group [PSP, 300 mg/(kg · d)]. After 6 weeks of intervention with PSP, rat serum was collected, and the spleen and thymus were stripped, and weighed. Serum IgG, IgM, LPS and IL-1 ß and IL-6 contents were detected by ELISA, and HE staining was adopted to observe the pathological changes of the colon tissue. [Results] PSP reduced the level of LPS caused by high-fat diet and the levels of inflammatory factors IL-6 and TNF-a, increased the indexes of the thymus and spleen serving as immune organs, increased IgG and IgM contents, and alleviated pathological damage to the colon tissue caused by high-fat diet. [Conclusions] This study provides a theoretical basis and experimental basis for the development of drugs for treating metabolic diseases such as obesity and inflammation.
- Subjects
POLYSACCHARIDES; HIGH-fat diet; PATHOLOGICAL physiology; IMMUNOGLOBULIN M; RATS; DRUG development; METABOLIC disorders; FAT
- Publication
Agricultural Biotechnology (2164-4993), 2023, Vol 12, Issue 4, p8
- ISSN
2164-4993
- Publication type
Article
- DOI
10.19759/j.cnki.2164-4993.2023.04.002