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- Title
Young Chinese adults with new onset of diabetic ketoacidosis – clinical course, autoimmune status and progression of pancreatic β-cell function.
- Authors
Li, J. K. Y.; Chan, J. C. N.; Zimmet, P. Z.; Rowley, M. J.; Mackay, I. R.; Cockram, C. S.
- Abstract
Abstract Aims To examine the clinical course, autoimmune status and pancreatic β cell function, over a 2-year period, in young Chinese subjects newly presenting with diabetic ketoacidosis (DKA). Methods A prospective study involving 562 out of 27 893 patients who were admitted to the medical ward with a principal diagnosis of diabetes mellitus during the recruitment period of 1 year. Results Of these 562 patients, 27 were aged less than 35 years and admitted with a diagnosis of DKA and 11 (six males and five females) of these were newly diagnosed. Antibodies to glutamic acid decarboxylase (GAD) were present in five patients. Anti-ICA 512 was not detected in any of the patients. Basal and post-glucagon stimulated plasma C-peptide remained in the insulin-deficient range although showing improvement at 2 years. Conclusions These findings confirm the relative rarity of autoimmune Type 1 diabetes in young Chinese. Even when the clinical presentation takes the extreme form of acute DKA, less than 50% have positive autoimmune markers.
- Subjects
CHINA; DIABETIC acidosis; CHINESE people; PANCREATIC beta cells; AUTOIMMUNITY; HEALTH
- Publication
Diabetic Medicine, 2000, Vol 17, Issue 4, p295
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2000.00273.x