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- Title
The effect of long-term glycaemic control on serum lipoprotein(a) levels in patients with Type 2 diabetes mellitus.
- Authors
Song, K. -H.; Ahn, Y. -B.; Yoon, K. -H.; Cha, B. -Y.; Lee, K. -W.; Son, H. -Y.; Kang, S. -K.
- Abstract
Summary Aims To examine whether long-term glycaemic control affects lipoprotein(a) (Lp(a)) levels in patients with Type 2 diabetes mellitus. Methods Eighty-nine Type 2 diabetic patients (38 men, 51 women) were recruited from the diabetes clinic. Based on HbA1c concentrations at baseline, patients were divided into two groups: those with HbA1c < 8.0% (n = 45) and those with HbA1c ≥ 8.0% (n = 44). Comparisons of Lp(a) levels were made between both groups. The effect of long-term glycaemic control on Lp(a) levels was investigated in a subgroup of 20 patients, selected from those with baseline HbA1c ≥ 8%. All these patients were treated with a goal of HbA1c < 7%. Results Lp(a) levels were not significantly different between those with HbA1c < 8.0% and those with HbA1c ≥ 8.0%. No correlation between Lp(a) and HbA1c or fasting blood glucose levels was noted in diabetic patients as a whole. After 2 years of intensive glycaemic control, all patients exhibited remarkable improvement of therapy: their average HbA1c levels were 6.5 ± 0.7%, being < 7% in 70% of patients. However, no change in Lp(a) levels were observed after 2 years (19.5 ± 14.8–21.4 ± 13.4 mg/dl, P = 0.390). Conclusion These results indicate that improvement of glycaemic control does not affect serum Lp(a) levels in patients with Type 2 diabetes mellitus.
- Subjects
LIPOPROTEIN A; DIABETES complications
- Publication
Diabetic Medicine, 1999, Vol 16, Issue 12, p1036
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.1999.00183.x