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- Title
Late-onset Leber hereditary optic neuropathy.
- Authors
Pfeiffer, Margaret L; Hashemi, Nafiseh; Foroozan, Rod; Lee, Andrew G
- Abstract
Background While Leber hereditary optic neuropathy typically causes bilateral visual loss in the second through fourth decades, we highlight visual loss from Leber hereditary optic neuropathy in older patients to characterize the clinical features of this cohort. Design Retrospective case series. Participants Patients seen between January 2003 and July 2012 at Baylor College of Medicine and between April 2010 and July 2012 at The Methodist Hospital in Houston, Texas. Methods Patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were identified via retrospective chart review. Main Outcome Measures Clinical courses of patients. Results Five patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were greater than 60 years of age at the time of visual loss (range 62-70 years, mean 66.4 ± 3.0). Conclusion This series reinforces the importance of including Leber hereditary optic neuropathy in the differential diagnosis of patients of any age with optic neuropathy.
- Subjects
LEBER'S hereditary optic atrophy; VISION disorders; OLDER patients; MITOCHONDRIAL Disorders: From Pathophysiology to Acquired Defect (Book); RETROSPECTIVE studies; BAYLOR College of Medicine
- Publication
Clinical & Experimental Ophthalmology, 2013, Vol 41, Issue 7, p690
- ISSN
1442-6404
- Publication type
Article
- DOI
10.1111/ceo.12091