We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Weight loss and response to chemotherapy in pediatric patients with osteosarcoma.
- Authors
Peled, Yair; Levin, Dror; Manisterski, Michal; Kollander, Netania; Shukrun, Rachel; Elhasid, Ronit
- Abstract
Background: Weight loss and malnutrition are common findings in pediatric oncology patients, but their prognostic significance is controversial. We sought to evaluate the correlation between weight loss and response to neo-adjuvant chemotherapy in pediatric patients with osteosarcoma. Procedure: All medical files of patients treated for osteosarcoma in a single pediatric haemato-oncology center between January 2011 and October 2022 were retrospectively reviewed. Results: Sixty-three patients were suitable for study inclusion. Data on changes in their body weight between the initiation of neo-adjuvant chemotherapy and local therapy (tumor resection) were extracted. Response to chemotherapy was assessed by the percentage of tumor necrosis at the time of surgery. There was a significant direct correlation between a weight loss of 3% and above and good response to chemotherapy as demonstrated by tumor necrosis above 90%. Conclusions: Low caloric intake may imitate a caloric restriction diet that was proven to improve response to therapy in some oncological diseases. Further prospective trials are needed for the establishment of recommended caloric intake during chemotherapy in pediatric patients with osteosarcoma.
- Subjects
WEIGHT loss; OSTEOSARCOMA; TUMORS in children; TREATMENT effectiveness; DESCRIPTIVE statistics; RETROSPECTIVE studies; MANN Whitney U Test; CHI-squared test; CANCER chemotherapy; LONGITUDINAL method; COMBINED modality therapy; DATA analysis software
- Publication
European Journal of Clinical Nutrition, 2024, Vol 78, Issue 6, p541
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/s41430-024-01404-0