We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ساخت بررسی خصوصیات فیزیکوشیمیایی و مطالعات پایداری فرمولاسیون ژل از لائیک اسید.
- Authors
سعید قاسمی; زهرا صبور; محمد مؤذن; سعید منوچهری
- Abstract
Background Rosacea as a skin inflammatory disease may be triggered by some types of bacteria. Azelaic acid with antibacterial property can be used for treatment of skin conditions such as Rosacea. Objective In this study, we aim to prepare and evaluate the physicochemical properties and primary stability of 15% azelaic acid gel. Methods For the gel preparation, first, an aqueous solution containing ethylenediaminetetraacetic and benzoic acids was prepared. Then, a mixture of polysorbate 80 and triglyceride was added to the solution at 50°C. Then, lecithin, propylene glycol, and carbomer 940 P was added to the mixture, and stirred. After that, the gel was prepared. Then, 15 g of dissolved azelaic acid in propylene glycol was added to the gel. Finally, the formulation was homogenized for 15 min. Results On the day of production, all the formulations had a smooth appearance and the amount of azelaic acid was about 15%. In the preliminary stability study for 3 months, the amount of azelaic acid in the formulation 5 (F5), prepared using homogenizer, was more than 99% of drug content, without any significant difference with other formulations. The released drug from F5 was 30% in the first hour and 50% after 2 hours. Conclusion All prepared formulations have acceptable pH, viscosity, and drug content. In 3 months, the highest homogeneity of azelaic acid with the lowest standard deviation was seen in the F5 formulation, indicating the importance of using homogenizer in azelaic acid gel preparation. Also, the propylene glycol 18% w/w, in addition to having a co-solvent role, can increase the release of azelaic acid from the gel.
- Subjects
PROPYLENE glycols; ETHYLENEDIAMINETETRAACETIC acid; ROSACEA; PHARMACEUTICAL gels; DRUG delivery systems; LECITHIN; PHYSICAL &; theoretical chemistry; SOLVENTS; DICARBOXYLIC acids; DOSAGE forms of drugs; BENZOATES; SURFACE active agents; TRIGLYCERIDES
- Publication
Journal of Guilan University of Medical Sciences, 2024, Vol 33, Issue 1, p74
- ISSN
2008-4048
- Publication type
Article
- DOI
10.32598/JGUMS.33.1.495.1