We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers.
- Authors
Farkas, Noémi-Izabella; Marincaș, Laura; Barbu-Tudoran, Lucian; Barabás, Réka; Turdean, Graziella Liana
- Abstract
Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.
- Subjects
DOXYCYCLINE; CARBON electrodes; PHYSISORPTION; NANOFIBERS; SCANNING electron microscopy
- Publication
Journal of Functional Biomaterials, 2023, Vol 14, Issue 6, p331
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb14060331