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- Title
Evaluation of an Injectable Biphasic Calcium Sulfate/Hydroxyapatite Cement for the Augmentation of Fenestrated Pedicle Screws in Osteoporotic Vertebrae: A Biomechanical Cadaver Study.
- Authors
Tian, Xinggui; Raina, Deepak B.; Vater, Corina; Kilian, David; Ahlfeld, Tilman; Platzek, Ivan; Nimtschke, Ute; Tägil, Magnus; Lidgren, Lars; Thomas, Alexander; Platz, Uwe; Schaser, Klaus-Dieter; Disch, Alexander C.; Zwingenberger, Stefan
- Abstract
Cement augmentation of pedicle screws is one of the most promising approaches to enhance the anchoring of screws in the osteoporotic spine. To date, there is no ideal cement for pedicle screw augmentation. The purpose of this study was to investigate whether an injectable, bioactive, and degradable calcium sulfate/hydroxyapatite (CaS/HA) cement could increase the maximum pull-out force of pedicle screws in osteoporotic vertebrae. Herein, 17 osteoporotic thoracic and lumbar vertebrae were obtained from a single fresh-frozen human cadaver and instrumented with fenestrated pedicle screws. The right screw in each vertebra was augmented with CaS/HA cement and the un-augmented left side served as a paired control. The cement distribution, interdigitation ability, and cement leakage were evaluated using radiographs. Furthermore, pull-out testing was used to evaluate the immediate mechanical effect of CaS/HA augmentation on the pedicle screws. The CaS/HA cement presented good distribution and interdigitation ability without leakage into the spinal canal. Augmentation significantly enhanced the maximum pull-out force of the pedicle screw in which the augmented side was 39.0% higher than the pedicle-screw-alone side. Therefore, the novel biodegradable biphasic CaS/HA cement could be a promising material for pedicle screw augmentation in the osteoporotic spine.
- Subjects
CALCIUM sulfate; SCREWS; SPINAL canal; HYDROXYAPATITE; OSTEOPOROSIS; VERTEBRAE; LUMBAR vertebrae
- Publication
Journal of Functional Biomaterials, 2022, Vol 13, Issue 4, p269
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb13040269