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- Title
Effect of Sulpiride on Plasma Prolactin in Rats.
- Authors
Iwasaki, Y.; Kato, Y.; Chihara, K.; Ohgo, S.; Maeda, K.; Imura, H.
- Abstract
I.v. injection of sulpiride (S; 0.5-20 μg/100 g b.w.) caused a significant and dose-related increase in plasma prolactin (Prl) levels in urethane-anesthetized rats, with peak values occuring 10 min after the injection. L-dopa administration (2 mg/100 g b.w., i.v.) significantly blunted plasma Prl response to S (1 μg/100 g b.w., i.v.). S injection (1 μg/rat) into a lateral ventricle also raised plasma Prl significantly. Hypothalamic destruction resulted in a prominent increase of basal plasma Prl, which increased further following the injection of S. These results suggest that S stimulates Prl secretion by its possible direct action on the anterior pituitary. Copyright © 1976 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1976, Vol 21, Issue 3, p267
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000122532