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- Title
Efficacy and Safety of Azathioprine and 6-Mercaptopurine in Japanese Pediatric Patients with Ulcerative Colitis: A Survey of the Japanese Society for Pediatric Inflammatory Bowel Disease.
- Authors
Tajiri, Hitoshi; Tomomasa, Tsuyoshi; Yoden, Atsushi; Konno, Mutsuko; Sasaki, Mika; Maisawa, Shuniti; Sumazaki, Ryo; Shimizu, Toshikazu; Toyoda, Shigeru; Etani, Yuri; Nakacho, Mariko; Ushijima, Kosuke; Kobayashi, Akio
- Abstract
Background and Aims: Azathioprine (AZA) and 6-mercaptopurine (6-MP) have recently been used in Japanese pediatric patients with ulcerative colitis. The aims of this study were to evaluate both the therapeutic efficacy and safety of AZA/6-MP in this group of patients. Methods: Fourteen members of the Japanese Society for Pediatric Inflammatory Bowel Disease reported 35 retrospective cases that received AZA/6-MP and were evaluated for adverse drug effects. In those who tolerated AZA/6-MP, disease activity and corticosteroid doses before and during the first 6 months of therapy were assessed. Results: AZA or 6-MP was safely used in 21 of 35 patients (60%) without adverse drug effects. The disease activity began to decrease from the first month of therapy and the maximum effect was achieved after 3 months. The mean daily prednisolone dose was decreased from 26.9 to 11.6 mg and dose reduction was achieved in 58% of patients after 6 months of therapy. Fourteen of the 35 patients (40%) experienced adverse drug effects, including leukopenia (n = 11), aplastic anemia (n = 1), pancreatitis (n = 1) and liver dysfunction (n = 1). Conclusions: The majority of Japanese children with ulcerative colitis tolerated AZA/6-MP and experienced favorable effects. However, 40% experienced adverse drug effects, mainly myelosuppression. Copyright © 2008 S. Karger AG, Basel
- Subjects
JAPAN; LEUCOPENIA; ADRENOCORTICAL hormones; DRUG efficacy; ULCERATIVE colitis in children; DRUG side effects
- Publication
Digestion, 2008, Vol 77, Issue 3/4, p150
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000140974