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- Title
Studies on the anti–diarrheal properties of leaf extract of Desmodium puchellum.
- Authors
Rahman, Md. Khalilur; Barua, Soumitra; Islam, Md. Fokhrul; Islam, Md. Rafikul; Sayeed, Mohammed Abu; Parvin, Mst. Shahnaj; Islam, Md. Ekramul
- Abstract
Abstract: Objective: To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract of Desmodium puchellum (Family: Fabaceae) leaves. Methods: The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats. Both of the extracts were given to the rats at 200 mg/kg orally. Loperamide was used as a standard drug for diarrhea. Results: The diarrheal severity was reduced significantly (P<0.05) by methanol and petroleum ether extracts by 31.95% and 28.33%, respectively, whereas 54.75% inhibition was found for standard drug loperamide at 5 mg/kg. The two extracts also significantly (P<0.05) reduced the intestinal volume in case of castor oil induced enteropooling. Conclusions: It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential.
- Subjects
ANTIDIARRHEALS; LEGUMES; PLANT extracts; PHARMACOLOGY; LOPERAMIDE; THERAPEUTICS; DIARRHEA
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2013, Vol 3, Issue 8, p639
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(13)60129-X