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- Title
In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease.
- Authors
Glover, Joel C.; Aswendt, Markus; Boulland, Jean-Luc; Lojk, Jasna; Stamenković, Stefan; Andjus, Pavle; Fiori, Fabrizio; Hoehn, Mathias; Mitrecic, Dinko; Pavlin, Mojca; Cavalli, Stefano; Frati, Caterina; Quaini, Federico; EU COST Action 16122 (BIONECA)
- Abstract
Stem cell-based therapeutics is a rapidly developing field associated with a number of clinical challenges. One such challenge lies in the implementation of methods to track stem cells and stem cell-derived cells in experimental animal models and in the living patient. Here, we provide an overview of cell tracking in the context of cardiac and neurological disease, focusing on the use of iron oxide-based particles (IOPs) visualized in vivo using magnetic resonance imaging (MRI). We discuss the types of IOPs available for such tracking, their advantages and limitations, approaches for labeling cells with IOPs, biological interactions and effects of IOPs at the molecular and cellular levels, and MRI-based and associated approaches for in vivo and histological visualization. We conclude with reviews of the literature on IOP-based cell tracking in cardiac and neurological disease, covering both preclinical and clinical studies.
- Subjects
HEART diseases; NEUROLOGICAL disorders; STEM cells; IRON powder; HEART cells; LABORATORY animals
- Publication
Molecular Imaging & Biology, 2020, Vol 22, Issue 6, p1469
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-019-01440-4