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- Title
Statin use and pancreatic cancer risk in two prospective cohort studies.
- Authors
Hamada, Tsuyoshi; Khalaf, Natalia; Yuan, Chen; Babic, Ana; Morales-Oyarvide, Vicente; Qian, Zhi Rong; Nowak, Jonathan Andrew; Ng, Kimmie; Kraft, Peter; Rubinson, Douglas Adam; Stampfer, Meir Jonathan; Giovannucci, Edward Luciano; Fuchs, Charles Stewart; Ogino, Shuji; Wolpin, Brian Matthew
- Abstract
<bold>Background: </bold>Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are common lipid-lowering agents and may reduce the risk of several cancer types including pancreatic cancer. However, the association between statin use and pancreatic cancer risk has not been fully evaluated in prospective studies.<bold>Methods: </bold>We studied the association between statin use and incident pancreatic cancer in 113,059 participants from the prospective Nurses' Health Study and Health Professionals Follow-up Study. Statin use was self-reported via study questionnaires and updated biennially. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of pancreatic cancer were estimated using multivariable Cox proportional hazards models with adjustment for potential confounders.<bold>Results: </bold>In total, 583 participants developed incident pancreatic cancer during 1.4 million person-years of follow-up. No difference was identified in pancreatic cancer risk for regular versus non-regular statin users (multivariable-adjusted HR 0.98; 95% CI 0.82-1.16). There was no significant heterogeneity in the association of statin use with pancreatic cancer risk between the cohorts. Similarly, longer duration of regular statin use was not associated with decreased risk of pancreatic cancer (Ptrend = 0.65). The results remained similar when we examined statin use status at baseline or accounting for 4-year latency period. We observed no statistically significant effect modification for the association of statin use with pancreatic cancer risk by body mass index, smoking status, or diabetes mellitus status (all Pinteraction > 0.21).<bold>Conclusions: </bold>Regular statin use was not associated with pancreatic cancer risk in two large prospective cohort studies in the U.S.
- Subjects
UNITED States; STATINS (Cardiovascular agents); RISK factors of pancreatic cancer; CANCER prevention; COENZYME A; REDUCTASE inhibitors; ANTILIPEMIC agents; NURSES' Health Study; ADENOCARCINOMA; DIABETES; LONGITUDINAL method; PANCREATIC tumors; RESEARCH funding; SMOKING; BODY mass index; DISEASE incidence; PROPORTIONAL hazards models
- Publication
Journal of Gastroenterology, 2018, Vol 53, Issue 8, p959
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s00535-018-1430-x