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- Title
Kan Kültürlerinden İzole Edilen Maya Türlerinin Vıtek 2 Sistemi ile Tanımlanması ve Antifungal Duyarlılıkları.
- Authors
MUTLU SARIGÜZEL, Fatma; KOÇ, Ayşe Nedret; KARAGÖZ, Selma
- Abstract
Backgrounds: The aim of this study is to investigate the identification and antifungal susceptibilities with VITEK 2 Compact automated system (BioMérieux, France) of yeast strains isolated from blood cultures in Microbiology Laboratory, Kayseri Education and Research Hospital between January 2012-June 2014. TM Methods: A total of 175 yeast strainsisolated from blood cultures by BACTEC 9240 and BACTEC Fx automated system (Becton Dickinson, ABD) were included the study. The strains were identified by VITEK ® 2 Compact automated system YST ID card (BioMérieux, France)and antifungal susceptibilities for amphotericin B, caspofungin, flucytosine, fluconazole and voriconazole were determined with automated ® system VITEK 2 Compact AST YS06 card(BioMérieux, France). Results: A total of 175 strains were included in the study, 68 of them being C.albicans and 107 non-albicans Candida. The identification of 107 non-albicans yeast isolates were as follows: 67 Candida parapsilosis, 13 Candida glabrata, eight Candida famata, six Candida tropicalis, five Candida krusei, three Candida lusitaniae and Candida kefyr, two Candida guilliermondii. The resistance rates for fluconazole and amphotericin B among C.albicans strains were 2.9 % and 5.8 %, respectively. However, no resistance were detected against other antifungals. The resistance rates for amphotericin B,flucytosine fluconazole and voriconazole in non-albicans Candida strains were 8.4 %, 1.8 %, 7.4 % and 2.8 %, respectively. The rate of fluconazole dose-dependent susceptible non-albicans Candida strains were % 17.7. The antifungal susceptibility of C. famata strains could not be determined by Vitek 2 AST card. Conclusions: This study points out the importance of identifying yeast isolates to species level, because of the high frequency of non-albicans yeasts isolated from blood cultures. Species identification and reporting in vitro antifungal susceptibility results might help todirect diagnosis and treatment policies
- Subjects
FRANCE; AMPHOTERICIN B; AUTOMATION; BLOOD; CANDIDA albicans; CELL culture; DRUG resistance in microorganisms; HETEROCYCLIC compounds; LABORATORIES; MICROBIAL sensitivity tests; YEAST; FLUCONAZOLE; IN vitro studies; VORICONAZOLE
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2015, Vol 12, Issue 2, p261
- ISSN
1304-9623
- Publication type
Article