We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Does differentiated squamous intraepithelial neoplasia occur in the cervix?
- Authors
Busca, Aurelia; Djordjevic, Bojana; Mai, Kien T.
- Abstract
Objective: In this study, we describe the entity of differentiated cervical intraepithelial neoplasia (dCIN) where atypia is limited to the basal layer and examine its association with squamous cell carcinoma (SCC). Methods:We identified a pilot case of invasive cervical SCC developing from dCIN with increased intercellular widening and early keratosis and intraepithelial neoplastic spread above the parabasal layer (usual-like CIN pattern or u-like CIN). Squamous dysplasia, categorized into dCIN, u-like CIN and uCIN, was examined in 32 consecutive cases of cervical invasive SCC. Immunohistochemistry for p16 and p53 was performed. Results: Invasive SCC developed from dCIN/u-like CIN in 2 cases (Group 1), mixed dCIN/u-like CIN and uCIN in 15 cases (Group 2) and from pure uCIN in 15 (Group 3). pT1a invasive SCC was present in 2/2, 6/15 and 13/15 of Group 1, 2 and 3, respectively. In comparison to Group 3, Group 2 was associated with a higher rate of pT1b/T2 invasive SCC (n=9 vs 2, p<0.05) and tended to occur in younger patients (40±13 vs 51±10 years, p>0.05). uCIN/u-like CIN and dCIN areas had diffuse staining for p16 and showed linear basal/parabasal reactivity for p53. Conclusions: While its appearance may mimic low grade dysplasia, dCIN/u-like CIN is a more aggressive form of cervical dysplasia than uCIN, but unlike its analogue in the vulva, its pathogenesis is HPV-mediated.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p42
- ISSN
1918-915X
- Publication type
Article