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- Title
N‐Trifluoromethyl Succinimide as a New Reagent for Direct C−H Trifluoromethylation of Free Anilines.
- Authors
Liu, Hao; He, Xin; Chen, Zhicheng; Zhang, Jingchao; Fang, Xinjie; Sun, Zhizhong; Chu, Wenyi
- Abstract
N‐trifluoromethylsuccinimide (NTFS) as a new trifluoromethylation reagent was designed and prepared via Ag−CF3, and applied to the direct trifluoromethylation of free aniline, and a series of trifluoromethyl products were obtained with good yields. The practicability of the protocol was verified by a gram‐level experiment and the synthesis of the antiasthmatic drug Mabuterol. In addition, a possible radical mechanism was proposed and verified by related experiments. The protocol provided a new solution for C−H trifluoromethylation of free anilines.
- Subjects
SUCCINIMIDES; ANILINE; ANTIASTHMATIC agents; RADICALS (Chemistry); DRUG synthesis
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 8, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202300039