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- Title
Revolutionizing digestive system tumor organoids research: Exploring the potential of tumor organoids.
- Authors
Xiu, Zhian; Yang, Qian; Xie, Fusheng; Han, Feng; He, Weiwei; Liao, Weifang
- Abstract
Digestive system tumors are the leading cause of cancer-related deaths worldwide. Despite ongoing research, our understanding of their mechanisms and treatment remain inadequate. One promising tool for clinical applications is the use of gastrointestinal tract tumor organoids, which serve as an important in vitro model. Tumor organoids exhibit a genotype similar to the patient's tumor and effectively mimic various biological processes, including tissue renewal, stem cell, and ecological niche functions, and tissue response to drugs, mutations, or injury. As such, they are valuable for drug screening, developing novel drugs, assessing patient outcomes, and supporting immunotherapy. In addition, innovative materials and techniques can be used to optimize tumor organoid culture systems. Several applications of digestive system tumor organoids have been described and have shown promising results in related aspects. In this review, we discuss the current progress, limitations, and prospects of this model for digestive system tumors.
- Subjects
DIGESTIVE organs; ORGANOIDS; GASTROINTESTINAL tumors; ECOLOGICAL niche; TUMORS
- Publication
Journal of Tissue Engineering, 2024, p1
- ISSN
2041-7314
- Publication type
Article
- DOI
10.1177/20417314241255470