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- Title
Long-term Topical Oestrogen Treatment of Sun-exposed Facial Skin in Post-menopausal Women Does Not Improve Facial Wrinkles or Skin Elasticity, But Induces Matrix Metalloproteinase-1 Expression.
- Authors
Hyun-Sun YOON; Se-Rah LEE; Jin Ho CHUNG
- Abstract
It is controversial whether treatment with oestrogen stimulates collagen production or accumulation in sun-exposed skin. The aim of this study was to determine the effect of long-term treatment with topical oestrogen on photoaged facial skin, with regard to wrinkle severity, and expression of procollagen and matrix metalloproteinase-1 enzyme. Two groups of 40 post-menopausal women applied either 1 g of 1% oestrone or vehicle cream once daily to the face for 24 weeks. Visiometer R1-R5 values (skin wrinkles) and Cutometer values (skin elasticity) were not significantly improved in the oestrone group after 24 weeks of treatment. Type I procollagen immunostaining did not increase in the oestrone group compared with the control group. However, levels of matrix metalloproteinase-1 mRNA increased robustly (10.3 times) in oestrone-treated skin compared with vehicle-treated skin. Thus, treatment with topical oestrogen may be deleterious in ultraviolet-induced skin ageing, at least in part, through induction of matrix metalloproteinase-1 (MMP-1) expression in human skin.
- Subjects
ESTROGEN replacement therapy; WRINKLE treatment; PHYSIOLOGICAL effects of solar radiation; ELASTICITY (Physiology); EXTRACELLULAR matrix proteins; COLLAGEN
- Publication
Acta Dermato-Venereologica, 2014, Vol 94, Issue 1, p4
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1614