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- Title
Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment.
- Authors
Sun, Yue; Zhang, Wei; Wang, Menghui; Liu, Huijie; Li, Qun; Luo, Jiazhe; Zhao, Mengzhen; Liu, Shichen; Wang, Xiaolei
- Abstract
Bacterial keratitis (BK) is a principal factor contributing to corneal ulcers and ocular complications, and has become a significant killer of global vision health. Traditional antibiotic therapy has unsatisfactory therapeutic effect due to short residence time and low utilization rate of drug, and the long-term abuse of antibiotics can easily incur the prevalence of drug-resistant bacteria. Furthermore, antibiotics are not effective in addressing the excessive inflammatory response caused by infection. Here, we developed a terbium-doped zinc oxide constructed dual-light-responsive nitric oxide (NO)-releasing nanoparticle (ZT@P@B) and modified it on the surface of contact lenses (CL-ZT@P@B) to boost its bioavailability. In vitro and in vivo experimental results verified that ZT@P@B could simultaneously respond to green light (GL) and 808 nm near-infrared (NIR) without obvious damage to the eyes, releasing reactive oxygen species (ROS) and NO, which could effectively kill bacteria (including drug-resistant strains) and reduce inflammatory response. The platform provides a promising strategy for the prevention and treatment of BK.
- Subjects
BACTERIAL keratitis; NANOPARTICLES; NITRIC oxide; ANTIBIOTICS; NEAR infrared radiation
- Publication
Nano Research, 2023, Vol 16, Issue 1, p849
- ISSN
1998-0124
- Publication type
Article
- DOI
10.1007/s12274-022-4744-1