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- Title
New Sesterterpenoid from the Marine Fungus Penicillium oxalicum M893.
- Authors
Nguyen, Thi Hoang Anh; Do, Thi Quynh; Nguyen, Thuy Linh; Le Thi, Hong Minh; Nguyen, Mai Anh; Murphy, Brian T; Dam, Thanh Xuan; Huong, Doan Thi Mai; Cuong, Pham Van
- Abstract
Objectives: The aim of the project was the isolation, structural elucidation, and antimicrobial and antifungal activities of compounds from the culture broth of the marine fungus Penicillium oxalicum M893 (isolated from the marine brown alga Spatoglossum sp.). Methods: Combined chromatographic techniques were used to isolate antibacterial and antifungal compounds from the MeOH extract Penicillium oxalicum M893. The structures were elucidated by analyses of high-resolution electrospray ionization mass spectral and nuclear magnetic resonance data. The antimicrobial and antifungal effects of compounds were evaluated using the dilution turbidimetric broth method. Results: One new sesterterpenoid, oxaliterpenoid (1), and six known compounds, aspergillusidone C (2), nidulin (3), emeguisin B (4), aspergillusether A (5), aspergillusether J (6), and guisinol (7) were isolated from the methanol extract of the culture broth of Penicillium oxalicum M893. All compounds showed potent antibacterial activities against Gram-(+) bacteria, E. faecalis (ATCC299212), S. aureus (ATCC25923), and B. cereus (ATCC14579), and the yeast Candida albicans (ATCC10231), with MIC values ranging from 2 to 128 µg/mL. Graphical Abstract This is a visual representation of the abstract.
- Subjects
PENICILLIUM; MARINE fungi; NUCLEAR magnetic resonance; BROWN algae; MARINE algae; CANDIDA albicans
- Publication
Natural Product Communications, 2023, Vol 18, Issue 8, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X231191636