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- Title
Chemical Constituents From the Marine Microalgae Thraustochytrium pachydermum.
- Authors
Thuy, Nguyen Thi Thu; Minh Hien, Hoang Thi; Ha, Nguyen Cam; Thom, Le Thi; Hong, Dang Diem; Thinh, Nguyen Van; Dan, Nguyen Trong; Hoi, Nguyen Dang; Loan, Vu Thi; Quang, Hoang Duc; Hang, Dan Thi Thuy; Kiem, Phan Van; Dat, Nguyen Tien; Nhiem, Nguyen Xuan
- Abstract
Objectives: Isolation, structure determination, and antimicrobial activities evaluation of compounds from the methanol extract of the marine microalga Thraustochytrium pachydermum TSL10. Methods: Using chromatographic methods to isolate compounds from the methanol extract of the T pachydermum. The chemical structures were elucidated by analyses of HR-ESI-MS and NMR spectral data. The antimicrobial activities of compounds were evaluated using the dilution turbidimetric broth method as the standard protocol published by the Clinical and Laboratory Standard Institute. Results: One new sterol, (24 R)-ergosta-7,22-diene-3 β,5 α,9 α -triol (1), and 16 known compounds, ergosta-7,22-diene-3 β,5 α- diol (2), cerevisterol (3), (22 E,24 S)-5 α,6 α -epoxy-ergosta-8(9),22-diene-3 β,7 α -diol (4), ergosterol (5), 5 α,8 α -epidioxyergosta-6,22-diene-3 β -ol (6), linoleic acid (7), 4-((9 Z,12 Z)-octadeca-9,12-dienoyloxy)butanoic acid (8), 1-linoleoyl-sn-glycero-3-phosphocholine (9), cibotiglycerol (10), gingerglycolipid B (11), oleic acid (12), 4-((9Z)-octadec-9-enoyloxy)butanoic acid (13), (2 S)-1- O -(9 Z)-octadec-9-enoyl)-3- O -(6-sulfo-D-quinovopyranosyl)glycerol (14), 6′- O -linoleylsucrose (15), gingerglycolipid C (16), and (S)-3-stearoyl- sn -glycerol (17) were identified from the marine microalga Thraustochytrium pachydermum TSL10. Sterols 1–6 were found to exhibit significant antimicrobial activities on Gram-(+) bacteria (Enterococcus faecalis ATCC29212, Staphylococcus aureus ATCC25923, and Bacillus cereus ATCC14579) and the yeast (Candida albicans ATCC10231) with MIC values ranging from 32 to 256 µg/mL. Conclusions: The results suggested sterols 1–6 could be potential antimicrobial agents against Gram-(+) bacteria. Graphical Abstract This is a visual representation of the abstract.
- Publication
Natural Product Communications, 2023, Vol 18, Issue 3, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X231157145