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- Title
Autoimmune pulmonary alveolar proteinosis and sarcoidosis in the same patient: Case report and systematic review.
- Authors
Shrestha, Deepa; Muthu, Valliappan; Sehgal, Inderpaul S.; Bal, Amanjit; Agarwal, Ritesh; Dhooria, Sahajal
- Abstract
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder characterized by surfactant accumulation in the alveolar spaces while sarcoidosis is a multisystem granulomatous disease of unknown etiology. The occurrence of PAP and sarcoidosis in the same patient is rare. A 37-year-old woman presented with cough and breathlessness and was diagnosed to have autoimmune PAP. She responded well to subcutaneous injections of recombinant granulocyte macrophage colony stimulating factor. Three years later, she developed fever, chest pain, cough, and facial palsy. The evaluation revealed a diagnosis of sarcoidosis that responded to immunosuppressive treatment. We discuss the link between PAP and sarcoidosis and review the literature on this association.
- Subjects
SARCOIDOSIS; PULMONARY alveolar proteinosis; GRANULOCYTE-colony stimulating factor; MACROPHAGE colony-stimulating factor; SUBCUTANEOUS injections; FACIAL paralysis
- Publication
Lung India, 2022, Vol 39, Issue 5, p466
- ISSN
0970-2113
- Publication type
Article
- DOI
10.4103/lungindia.lungindia_127_22