We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunogenetics: Safety in numbers.
- Authors
Melief, Cornelis J. M.
- Abstract
The article provides information about immune receptor genes in relation to HIV virus. The article states that duplications of immune receptor genes can have on HIV susceptibility and progression to AIDS. The HIV virus utilizes three major receptors of the immune system to beat this system from within. These are the CD4 co-receptor on CD4þ T-helper cells, the CCR5 chemokine receptor on T-cells and the DC sign receptor on antigen presenting dendritic cells (DCs). The virus utilizes these receptors to attack to, penetrate into and replicate in mainly CD4þ T cells and it eventually destroys and depletes them. In the case of DC sign, this appears to allow DCs to transport HIV towards central lymphoid organs to gain better access to T lymphocytes.
- Subjects
GENES; HIV; IMMUNE system; CELL receptors; AIDS; LYMPHOCYTES; HEREDITY; DENDRITIC cells
- Publication
European Journal of Human Genetics, 2005, Vol 13, Issue 7, p795
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201434