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- Title
Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
- Authors
Werner, Andrea K.; Romeis, Tina; Witte, Claus-Peter
- Abstract
The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms.
- Subjects
METABOLISM; NUCLEOTIDE sequence; GENOMES; GENETIC research; ENZYMES; ARABIDOPSIS thaliana; ESCHERICHIA coli
- Publication
Nature Chemical Biology, 2010, Vol 6, Issue 1, p19
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.265