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- Title
Human Chrysomya bezziana myiasis: A systematic review.
- Authors
Zhou, Xianyi; Kambalame, Dzinkambani Moffat; Zhou, Sitong; Guo, Xiang; Xia, Dan; Yang, Yemei; Wu, Rangke; Luo, Juan; Jia, Fenglong; Yuen, Mingchi; Xu, Yuehua; Dai, Geyang; Li, Li; Xie, Tian; Puthiyakunnon, Santhosh; Wei, Wenxia; Xie, Lixian; Liang, Siting; Feng, Yuqin; Huang, Songgen
- Abstract
Myiasis due to Old World screw-worm fly, Chrysomya bezziana, is an important obligate zoonotic disease in the OIE-list of diseases and is found throughout much of Africa, the Indian subcontinent, southeast and east Asia. C. bezziana myiasis causes not only morbidity and death to animals and humans, but also economic losses in the livestock industries. Because of the aggressive and destructive nature of this disease in hosts, we initiated this study to provide a comprehensive understanding of human myiasis caused by C. bezziana. We searched the databases in English (PubMed, Embase and African Index Medicus) and Chinese (CNKI, Wanfang, and Duxiu), and international government online reports to 6th February, 2019, to identify studies concerning C. bezziana. Another ten human cases in China and Papua New Guinea that our team had recorded were also included. We retrieved 1,048 reports from which 202 studies were ultimately eligible for inclusion in the present descriptive analyses. Since the first human case due to C. bezziana was reported in 1909, we have summarized 291 cases and found that these cases often occurred in patients with poor hygiene, low socio-economic conditions, old age, and underlying diseases including infections, age-related diseases, and noninfectious chronic diseases. But C. bezziana myiasis appears largely neglected as a serious medical or veterinary condition, with human and animal cases only reported in 16 and 24 countries respectively, despite this fly species being recorded in 44 countries worldwide. Our findings indicate that cryptic myiasis cases due to the obligate parasite, C. bezziana, are under-recognized. Through this study on C. bezziana etiology, clinical features, diagnosis, treatment, epidemiology, prevention and control, we call for more vigilance and awareness of the disease from governments, health authorities, clinicians, veterinary workers, nursing homes, and also the general public. Chrysomya bezziana larvae are characterized by feeding aggressively on the living tissues and body fluids of the host. The dreadful feelings of patients suffering from myiases with severe tissue and bone destruction, even death, and the enormous economic losses in the livestock industries have been described previously. But our findings indicate that C. bezziana myiases still appear to be under-recognized as a serious medical or veterinary condition throughout the world. Both in China and the world at large, it is probable that C. bezziana distribution could well be greater than currently reported. Our study provides an opportunity for clinicians and health authorities to gain a comprehensive understanding of this disease from its etiology, clinical features, diagnosis, treatment, epidemiology, prevention and control. In addition, our findings will engage governments, health staff, veterinary workers, aged-care facilities, and also the general public, in efforts to recognize, prevent, and control such infestations.
- Subjects
MYIASIS; META-analysis; ANIMAL mortality; ANIMAL industry; ZOONOSES; SCREWWORM
- Publication
PLoS Neglected Tropical Diseases, 2019, Vol 13, Issue 10, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0007391