We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Obesity and Breast Cancer: Interaction or Interference with the Response to Therapy?
- Authors
Riondino, Silvia; Formica, Vincenzo; Valenzi, Elena; Morelli, Cristina; Flaminio, Valeria; Portarena, Ilaria; Torino, Francesco; Roselli, Mario
- Abstract
Background: Aromatase inhibitors (AI) are widely used for treating hormone-sensitive breast cancer (BC). Obesity, however, due to aromatase-mediated androgen conversion into estradiol in the peripheral adipose tissue, might impair AI inhibitory capacity. We aimed at identifying a cut-off of body mass index (BMI) with significant prognostic impact, in a cohort of stage I-II BC patients on systemic adjuvant therapy with AI. Methods: we retrospectively evaluated routinely collected baseline parameters. The optimal BMI cut-off affecting disease-free survival (DFS) in AI-treated BC patients was identified through maximally selected rank statistics; non-linear association between BMI and DFS in the AI cohort was assessed by hazard-ratio-smoothed curve analysis using BMI as continuous variable. The impact of the BMI cut-off on survival outcomes was estimated through Kaplan–Meier plots, with log-rank test and hazard ratio estimation comparing patient subgroups. Results: A total of 319 BC patients under adjuvant endocrine therapy and/or adjuvant chemotherapy were included. Curve-fitting analysis showed that for a BMI cut-off >29 in AI-treated BC patients (n = 172), DFS was increasingly deteriorating and that the impact of BMI on 2-year DFS identified a cut-off specific only for the cohort of postmenopausal BC patients under adjuvant therapy with AI. Conclusion: in radically resected hormone-sensitive BC patients undergoing neoadjuvant or adjuvant chemotherapy and treated with AI, obesity represents a risk factor for recurrence, with a significantly reduced 2-year DFS.
- Subjects
BREAST cancer; OBESITY; MEDICAL care; CANCER treatment; HEALTH outcome assessment
- Publication
Current Oncology, 2023, Vol 30, Issue 1, p1220
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30010094