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- Title
PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE.
- Authors
Bashir, Sajid; Jamshaid, Mohammad; Ahmad, Bashir; Iqbal, Javeid
- Abstract
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
- Subjects
LIQUID chromatography; RABBIT anatomy; PHARMACOKINETICS; CIPROFLOXACIN; QUINOLONE antibacterial agents; CONCENTRATION functions; DRIED foods
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2008, Vol 21, Issue 3, p225
- ISSN
1011-601X
- Publication type
Article